If the game runs and the pointer is offset and buttons cannot be clicked when they are highlighted or hovered over.

To resolve this -

1. Located the game exe file. Stronghold Crusader 2 would be located here -
C:\Program Files (x86)\Steam\steamapps\common\Stronghold Crusader 2\bin\win32_release
2. Select the exe file such as - Crusader2.exe
3. Right click on the exe and click on the Compatibility tab and tick 'Disable display scaling on high DPI settings'
4. Click on OK and run the game as normal.

You can find you DPI (Scaling)
1. Type DPI into the and click on 'Make text and other items larger or smaller'
Or select -
Control Panel\Appearance and Personalisation\Display
2. Click on 'set a custom scaling level'